Microwave-assisted synthesis of 5-carboxymethoxy-N-acetyltryptamine derivatives
✍ Scribed by Adriana Fı̂naru; Aurélie Berthault; Thierry Besson; Gérald Guillaumet; Sabine Berteina-Raboin
- Book ID
- 104232314
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- French
- Weight
- 140 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
The synthesis of the indole core structure was investigated using microwave irradiation. The experimental microwave conditions described allow significant rate enhancements and good yields compared to conventional reaction conditions.
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## Abstract A series of 3‐alkyl(aryl)‐4‐(__p__‐hydroxy‐phenyl)‐4,5‐dihydro‐1__H__‐1,2,4‐triazol‐5‐ones **2** were obtained from the reaction of alkyl (aryl) ester ethoxycarbonyl hydrazones **1** with __p__‐hydroxy aniline. The reaction of **1** with 1,4‐diamino benzene (1:1) to afford 3‐alkyl(aryl)