Synthesis and topoisomerase II inhibitor
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Younghwa Na; Jung-Min Nam
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Article
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2011
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Elsevier Science
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English
β 279 KB
In order to find potential anticancer drug candidate targeting topoisomerases enzyme, we have designed and synthesized oxiranylmethoxy-and thiiranylmethoxy-retrochalcone derivatives and evaluated their pharmacological activity including topoisomerases inhibitory and cytotoxic activity. Of the compou