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Microwave-assisted synthesis and evaluation of antimicrobial activity of 3-{3-(s-aryl and s-heteroaromatic)acryloyl}-2H-chromen-2-one derivatives

✍ Scribed by Olayinka O. Ajani; Obinna C. Nwinyi

Publisher
Journal of Heterocyclic Chemistry
Year
2010
Tongue
English
Weight
126 KB
Volume
47
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

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The exploration of potential utilization of microwaves as an energy source for heterocyclic synthesis was herein investigated using condensation of 3‐acetylcoumarin (1) with aromatic and heteroaromatic aldehydes to afford the corresponding aromatic chalcones (2a, 2b, 2c, 2d, 2e, 2f, 2g, 2h, 2i, 2j) and heteroaromatic chalcones (3a, 3b, 3c, 3d, 3e and 4a, 4b, 4c, 4d, 4e), respectively, in good to excellent yield within 1–3 min. The chemical structures were confirmed by analytical and spectral data. All the synthesized compounds were screened for their antibacterial activity and 3‐{3‐(4‐dimethylaminophenyl)acryloyl}‐2__H__‐chromen‐2‐one (2i) was discovered to be the most active at minimum inhibitory concentration (MIC) value of 7.8 μg/mL. J. Heterocyclic Chem., (2010).

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