Microwave-assisted solvent-free parallel synthesis of thioamides

✍ Scribed by Roger Olsson; Henrik C Hansen; Carl-Magnus Andersson

• Publisher: Elsevier Science
• Year: 2000
• Tongue: French
• Weight: 58 KB
• Volume: 41
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)01360-5

✦ Synopsis

Rapid parallel synthesis of thioamides is described. A library of amides, synthesised by mixing acyl chlorides and diamines, was transformed into the corresponding thioamides utilising Lawesson's reagent as the oxygen/sulphur exchange reagent. Purification by solid-phase extraction afforded the library members in adequate purities and yields.