Microwave-assisted reactions: Three component process for the synthesis of 2-amino-2-chromenes under microwave heating
✍ Scribed by Ramadan A. Mekheimer; Kamal U. Sadek
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 2009
- Tongue
- English
- Weight
- 126 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0022-152X
- DOI
- 10.1002/jhet.13
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✦ Synopsis
Abstract
magnified image
A simple and efficient three component process for the synthesis of 2‐amino‐2‐chromenes utilizing the reaction of aryl aldehydes 1a, 1b, 1c, 1d, 1e, 1f, 1g, 1h with active methylenes 2a,b and 1‐naphthol 3 in refluxing ethanol/piperidine under microwave‐heating is described. J. Heterocyclic Chem., (2009).
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## Abstract magnified image A series of 2‐__p__‐tolylthiopyridine derivatives was directly synthesized __via__ three‐component reactions of chalcones, malononitrile, and 4‐methylbenzenethiol catalyzed by Et~3~N in DMF under microwave irradiation. It is an efficient and promising synthetic strategy