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Microwave-assisted one-pot synthesis of functionalized pyrimidines using ionic liquid

✍ Scribed by Dushyant Singh Raghuvanshi; Krishna Nand Singh

Publisher
Journal of Heterocyclic Chemistry
Year
2011
Tongue
English
Weight
75 KB
Volume
48
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

An efficient one‐pot multicomponent synthesis of 2,4‐diamino‐5‐pyrimidinecarbonitrile derivatives has been achieved in excellent yields by the condensation of aromatic aldehydes, malononitrile, and guanidine using ionic liquid under controlled microwave irradiation (100 W) at 60Β°C. This green approach offers a number of advantages in terms of methodology, high‐product yield, short reaction time, mild reaction conditions, and easy workup. J. Heterocyclic Chem., (2011).

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