Microwave-assisted, Mo(CO)6-mediated, palladium-catalyzed amino-carbonylation of aryl halides using allylamine: from exploration to scale-up

✍ Scribed by Prasad Appukkuttan; Linda Axelsson; Erik Van der Eycken; Mats Larhed

• Book ID: 104095616
• Publisher: Elsevier Science
• Year: 2008
• Tongue: French
• Weight: 188 KB
• Volume: 49
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2008.07.053

✦ Synopsis

Palladium-catalyzed aminocarbonylations of various (hetero)aryl halides with allylamine using Mo(CO) 6 as a solid, in situ CO source, were explored. Microwave-enhanced conditions proved to be highly useful in promoting the conversions in a mere 10-20 min with various (hetero)aryl iodides, bromides and chlorides. The scale-up of a microwave-enhanced aminocarbonylation to 25 mmol scale was performed successfully.