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Microwave-assisted efficient synthesis of benzo[4,5]imidazo[1,2-a]-pyrimidine derivatives in water under catalyst-free conditions

✍ Scribed by Shujiang Tu; Qingqing Shao; Dianxiang Zhou; Longji Cao; Feng Shi; Chunmei Li

Publisher
Journal of Heterocyclic Chemistry
Year
2007
Tongue
English
Weight
431 KB
Volume
44
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

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Benzo[4,5]imidazo[1,2‐a]pyrimidine derivatives were synthesized via the three‐component reaction of aldehyde, β‐dicarbonyl compound and 2‐aminobenzimidazole in water under microwave irradiation and without catalyst conditions. The new protocol has the advantages of higher yield, lower cost, reduced environment impact, wider scope and convenient procedure.

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✍ Minoo Dabiri; Hamid Arvin-Nezhad; Hamid R. Khavasi; Ayoob Bazgir 📂 Article 📅 2007 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 210 KB

## Abstract magnified image Pyrimido[4,5‐__d__]pyrimidine‐2,5‐dione derivatives have been synthesized in high yields in a novel, onepot, and efficient process by condensation of 6‐amino‐3‐methyl‐2‐(methylthio)pyrimidin‐4(3__H__)‐one, aldehydes and urea under microwave‐assisted conditions.