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Microwave-assisted döbner synthesis of 2-phenylquinoline-4-carboxylic acids and their antiparasitic activities

✍ Scribed by Gisela C. Muscia; Juan P. Carnevale; Mariela Bollini; Silvia E. Asís

Publisher
Journal of Heterocyclic Chemistry
Year
2008
Tongue
English
Weight
224 KB
Volume
45
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

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A series of twelve substituted 2‐phenylquinoline‐4‐carboxylic acids analogous to antimalarial and antileishmanial natural products was developed via the Döbner reaction employing microwave irradiation (MW). The products were obtained in moderate yields in 0.5‐3 minutes and nine of them were evaluated in vitro against the parasites responsible for malaria, leishmaniasis and trypanosomiasis diseases (WHO, Switzerland). Four compounds exhibited activity against Trypanosoma cruzi and another two resulted active against Plasmodium falciparum and Leishmania infantum, respectively.

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