Microwave-assisted claisen rearrangement. Application to the synthesis of angelicin derivatives

✍ Scribed by Hassan Valizadeh; Abbas Shockravi

• Publisher: Journal of Heterocyclic Chemistry
• Year: 2006
• Tongue: English
• Weight: 201 KB
• Volume: 43
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.5570430336

✦ Synopsis

Abstract

magnified image

4′‐(Hydroxy, chloro, amino, acetoxy and methoxy)‐methyl‐4,5′‐dimethylangelicins were efficiently and rapidly synthesized via Claisen rearrangement of 4‐methyl‐7‐[4‐(hydroxy, chloro, amino, acetoxy and methoxy)‐but‐2‐ynyloxy]‐coumarins respectively under microwave irradiation. Prominent among the advantages of this new method are operational simplicity, good yields in short reaction times and easy work‐up procedures employed.