Microwave applications in radiolabelling with short-lived positron-emitting radionuclides

✍ Scribed by Sharon Stone-Elander; Nils Elander

• Publisher: John Wiley and Sons
• Year: 2002
• Tongue: French
• Weight: 250 KB
• Volume: 45
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/jlcr.593

✦ Synopsis

Abstract

The use of microwave dielectric heating to reduce reaction times in organic transformations is rapidly increasing worldwide. Besides the time gains from simply performing reactions faster, other advantages have been noted, e.g. cleaner reaction mixtures due to decreased sample decomposition and altered product distributions as well as improved chemical flexibility due to the ability to accelerate typically sluggish reactions of less activated substrates. Microwave applications in radiolabelling tracers for positron emission tomography, paralleling and sometimes preceding developments in other areas of microwave‐enhanced chemistry, are reviewed here. Copyright © 2002 John Wiley & Sons, Ltd.