Microwave- and ultrasound-assisted Suzuki–Miyaura cross-coupling reactions catalyzed by Pd/PVP

✍ Scribed by Andréa Luzia F. de Souza; Lucyane C. da Silva; Bianca L. Oliveira; O.A.C. Antunes

• Book ID: 104095330
• Publisher: Elsevier Science
• Year: 2008
• Tongue: French
• Weight: 140 KB
• Volume: 49
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2008.04.061

✦ Synopsis

Suzuki-Miyaura reactions using Pd/PVP as a catalyst source were carried out in water-ethanol solution. Under MW, sonication or thermal condition yields were very similar, from moderate to very good, in a variety of examples. However, TOFs were very different, 750/h under MW, 250/h under sonication, and 28/h under thermal conditions. Studies carried out under sonication showed that the whole system after product extraction can be re-used at least twice without any noticeable loss of yield.