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Microvascular invasion of the seminal vesicles in adenocarcinoma of the prostate

✍ Scribed by Graham, Sam D.; Napalkov, Pavel; Watts, Lynda; Salomao, Diva; Bostwick, David G.

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 424 KB
Volume: 28
Category: Article
ISSN: 0270-4137
DOI: 10.1002/(sici)1097-0045(199606)28:6<359::aid-pros4>3.0.co;2-5

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✦ Synopsis

The objective of this article is to determine the relationship between microvascular invasion and seminal vesicle invasion in prostatic adenocarcinoma. Radical prostatectomies with seminal vesicle involvement were examined histologically and immunohistochemically with antibodies directed against S-100 protein and factor WI. Microvascular invasion of the seminal vesicles showed a positive correlation with microvascular and capsular invasion of the prostate (P = 0.006 and 0.048, respectively) and lymph node metastases. Tumor progression was found in 8 of 14 (57%) patients with microvascular invasion of the seminal vesicles, compared with 3 of 22 (14%) without microvascular invasion (P=O.OOl). Microvascular invasion of the seminal vesicles is predictive of tumor progression and lymph node metastases in prostatic adenocarcinoma.

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