Microtubule depolymerization and phosphorylation of c-Jun N-terminal kinase-1 and p38 were involved in gambogic acid induced cell cycle arrest and apoptosis in human breast carcinoma MCF-7 cells

6-Dehydrogingerdione, an active constitu

6-Dehydrogingerdione, an active constituent of dietary ginger, induces cell cycle arrest and apoptosis through reactive oxygen species/c-Jun N-terminal kinase pathways in human breast cancer cells

✍ Ya-Ling Hsu; Chung-Yi Chen; Ming-Feng Hou; Eing-Mei Tsai; Yuh-Jyh Jong; Chih-Hsi 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 476 KB 👁 1 views

## Abstract This study is the first to investigate the anticancer effect of 6‐dehydrogingerdione (DGE), an active constituent of dietary ginger, in human breast cancer MDA‐MB‐231 and MCF‐7 cells. DGE exhibited effective cell growth inhibition by inducing cancer cells to undergo G2/M phase arrest an