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Microstructural remodeling in the post-infarct porcine heart measured by diffusion tensor MRI and T1-weighted late gadolinium enhancement MRI

✍ Scribed by Geoffrey L Kung; Olujimi Ajijola; Rafael J Ramirez; Jin Kyu Gahm; Wei Zhou; N Wisniewski; Aman Mahajan; Alan Garfinkel; Kalyaman Shivkumar; Daniel Ennis


Publisher
BioMed Central
Year
2012
Tongue
English
Weight
586 KB
Volume
14
Category
Article
ISSN
1097-6647

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✦ Synopsis


The objective of this study was to quantify microstructural remodeling in peri-infarcted and infarcted porcine myocardium using diffusion tensor MRI (DT-MRI) for the first time. High resolution ex vivo late gadolinium enhanced (LGE) MRI was used to segment the DT-MRI data into normal, peri-infarct and infarcted myocardium.

LGE-MRI based segmentation produces regions with significantly different microstructural remodeling.