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Microsomal prostaglandin E synthase-2 is not essential for in vivo prostaglandin E2 biosynthesis

✍ Scribed by Leigh A. Jania; Subhashini Chandrasekharan; Michael G. Backlund; Nicholas A. Foley; John Snouwaert; I-Ming Wang; Patsy Clark; Laurent P. Audoly; Beverly H. Koller


Book ID
113865109
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
742 KB
Volume
88
Category
Article
ISSN
0090-6980

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Retinoic acid (RA) is a well-known antiinflammatory agent. In this study, we show that RA has a dual effect on cyclooxygenase-2 (COX-2) expression in inflammatory activated microglia, the resident brain macrophages. After treatment of microglia with LPS or thrombin, COX-2 expression was induced in t