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Microsomal prostaglandin E synthase-1 inhibition in cardiovascular inflammatory disease

✍ Scribed by M. Wang; W.-L. Song; Y. Cheng; G. A. FitzGerald


Book ID
108863472
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
286 KB
Volume
263
Category
Article
ISSN
0954-6820

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Expression of microsomal prostaglandin E
✍ M. Westman; M. Korotkova; E. af Klint; A. Stark; L. P. Audoly; L. Klareskog; A.- πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 372 KB

Objective. Microsomal prostaglandin E synthase 1 (mPGES-1) catalyzes the formation of PGE 2 from cyclooxygenase-derived PGH 2 . Microsomal PGES-1 is induced by proinflammatory cytokines and is strongly linked to conditions that result in high PGE 2 biosynthesis. PGE 2 contributes to the pathogenesis