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Microsatellite instability (MSI) increases with age in normal somatic cells

✍ Scribed by Mary I. Coolbaugh-Murphy; Jingping Xu; Louis S. Ramagli; Barry W. Brown; Michael J. Siciliano


Book ID
113775861
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
323 KB
Volume
126
Category
Article
ISSN
0047-6374

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## Abstract This study investigates the molecular features of metastasis in sporadic colon carcinomas with high‐level microsatellite instability (MSI‐H). DNA from 51 regions from 10 MSI‐H metastatic carcinomas and 26 corresponding metastases was analyzed for mutations in __TGFBRII__, __IGFIIR__, __