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Microsatellite instability, MLH-1 promoter hypermethylation, and frameshift mutations at coding mononucleotide repeat microsatellites in ovarian tumors

✍ Scribed by Esther Gras; Lluis Catasus; Rosmary Argüelles; Gema Moreno-Bueno; Jose Palacios; Carlos Gamallo; Xavier Matias-Guiu; Jaime Prat

Publisher: John Wiley and Sons
Year: 2001
Tongue: English
Weight: 194 KB
Volume: 92
Category: Article
ISSN: 0008-543X
DOI: 10.1002/1097-0142(20011201)92:11<2829::aid-cncr10094>3.0.co;2-3

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Frameshift mutations at coding mononucleotide repeat microsatellites in endometrial carcinoma with microsatellite instability

✍ Lluis Catasus; Xavier Matias-Guiu; Pilar Machin; Gian Franco Zannoni; Giovanni S 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 217 KB 👁 2 views

## Background: Microsatellite instability (mi) is a frequent occurrence in endometrioid carcinoma of the endometrium (ec). several genes known to contain mononucleotide short tracts in their coding sequences (tgf-beta rii, igfiir, bax, hmsh6, and hmsh3) are likely targets for mutations in these tum