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Microsatellite instability in colorectal cancer is associated with local lymphocyte infiltration and low frequency of distant metastases

✍ Scribed by Buckowitz, A; Knaebel, H-P; Benner, A; Bläker, H; Gebert, J; Kienle, P; von Knebel Doeberitz, M; Kloor, M


Book ID
109998484
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
248 KB
Volume
92
Category
Article
ISSN
0007-0920

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## Abstract This study investigates the molecular features of metastasis in sporadic colon carcinomas with high‐level microsatellite instability (MSI‐H). DNA from 51 regions from 10 MSI‐H metastatic carcinomas and 26 corresponding metastases was analyzed for mutations in __TGFBRII__, __IGFIIR__, __