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Microsatellite instability as a tool for the classification of gastric cancer

✍ Scribed by Andrew J.G Simpson; Otávia L Caballero; Sergio D.J Pena

Book ID: 117787578
Publisher: Elsevier Science
Year: 2001
Tongue: English
Weight: 69 KB
Volume: 7
Category: Article
ISSN: 1471-4914
DOI: 10.1016/s1471-4914(01)01916-5

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Microsatellite instability (MSI), which is recognized as an important mechanism in tumorigenesis, has been reported in familial gastric cancers (FGC). However, genetic defects responsible for this phenotype, that is, mutations in mismatchrepair genes such as hMLH1 and hMSH2, have not been detected i