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Microsatellite instability and expression of MLH1 and MSH2 in carcinomas of the small intestine

✍ Scribed by Karsten Schulmann; Stephan A. Hahn; Frank Brasch; Wolff Schmiegel


Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
80 KB
Volume
98
Category
Article
ISSN
0008-543X

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Mutations in the DNA mismatch repair (MMR) genes MLH1 and MSH2 have been linked to several human cancers which display the replication error (RER) phenotype. Germline mutations in these two genes have been implicated in about 90% of families with hereditary nonpolyposis colorectal cancer (HNPCC). A