Microsatellite Alterations on Chromosome 8 of Hepatocellular Carcinoma
β Scribed by Shuhui Zhang; Zhihong Xian; Wenming Cong; Mengchao Wu
- Publisher
- Springer
- Year
- 2004
- Tongue
- English
- Weight
- 205 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1610-1979
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract To elucidate the relationship between genomewide DNA hypomethylation and chromosome instability, 55 prostate carcinoma specimens were analyzed for extent of hypomethylation by Southern blot analysis of LINEβ1 sequence methylation and for loss or gain of chromosomal material by comparati
Hepatocellular carcinoma (HCC) is a common malignancy worldwide and highly associated with chronic virus-B or -C infection and cirrhosis. Molecular studies have shown high frequency of loss of heterozygosity (LOH) in some specific chromosome regions, but LOH on chromosome 9 in HCC has not been thoro
We investigated 24 hepatocellular carcinomas in Japan to find loss of heterozygosity with 15 polymorphic DNA markers that detect allelic losses at specific chromosome loci. Loss of heterozygosity on chromosomes lOq, 17p and 22q was detected in 3 of 12 (26%), 9 of 21 (43%) and 5 of 15 (33%) informati
## Abstract Loss of chromosome arm 8p, sometimes in combination with amplification of proximal 8p, is found in urothelial carcinoma (UC) and other epithelial cancers and is associated with more advanced tumor stage. We carried out array comparative genomic hybridization on 174 UC and 33 UC cell lin