MicroRNAs: Key Regulators of Oncogenesis

✍ Scribed by Sadegh Babashah (eds.)

Publisher: Springer International Publishing
Year: 2014
Tongue: English
Leaves: 449
Edition: 1
Category: Library

No coin nor oath required. For personal study only.

✦ Synopsis

Aberrant expression and function of microRNAs (miRNAs) in cancer have added a new layer of complexity to the understanding of development and progression of the disease state. It has been demonstrated that miRNAs have a crucial function in oncogenesis by regulating cell proliferation and apoptosis as oncogenes or tumor suppressors. The expression signatures of miRNAs provide exciting opportunities in the diagnosis, prognosis and therapy of cancer. Since miRNAs can function as either oncogenes or tumor suppressor genes in oncogenesis, the potential of using these small RNAs as therapeutic targets opens up new opportunities for cancer therapy by either inhibiting or augmenting their activity.

✦ Table of Contents

Front Matter....Pages i-xxvi
Front Matter....Pages 1-1
MicroRNAs and Cancer: An Overview....Pages 3-28
Epigenetics, MicroRNAs and Human Cancer....Pages 29-57
MicroRNAs, Diet and Cancer Chemoprevention....Pages 59-82
MicroRNAs and Energy Metabolism in Cancer Cells....Pages 83-95
MicroRNAs in Solid Tumors....Pages 97-127
MicroRNAs and Blood Cancers....Pages 129-153
MicroRNAs and Oncogenic Human Viruses....Pages 155-182
MicroRNAs Linking Cancer and Inflammation: Focus on Liver Cancer....Pages 183-208
MicroRNAs and Regulatory Pathways in Tumorigenesis....Pages 209-231
MicroRNA-Modulated Apoptotic and Autophagic Signaling Networks in Cancer....Pages 233-250
MicroRNAs in Cancer Drug Resistance and Drug Sensitivity....Pages 251-293
The Biological Roles of MicroRNAs in Cancer Stem Cells....Pages 295-320
Front Matter....Pages 321-321
MicroRNAs and Clinical Implications in Cancer....Pages 323-353
MicroRNA Expression Profiling and Its Clinical Impact in Breast Cancer....Pages 355-367
MicroRNAs and Their Clinical Impact on Resistance to Anticancer Treatment....Pages 369-386
Nanocarriers and MicroRNA-Based Scenarios for Cancer Therapy....Pages 387-411
Challenges and Strategies for Pulmonary Delivery of MicroRNA-Based Therapeutics....Pages 413-428
Back Matter....Pages 429-433

✦ Subjects

Cancer Research; Human Genetics; Gene Expression; Gene Function; Molecular Medicine; Drug Resistance

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