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MicroRNA expression in ACTH-producing pituitary tumors: up-regulation of microRNA-122 and -493 in pituitary carcinomas

✍ Scribed by Gail Stilling; Zhifu Sun; Shuya Zhang; Long Jin; Alberto Righi; Gάbor Kovācs; Mάrta Korbonits; Bernd W. Scheithauer; Kalman Kovacs; Ricardo V. Lloyd


Book ID
107571442
Publisher
Springer
Year
2010
Tongue
English
Weight
735 KB
Volume
38
Category
Article
ISSN
0969-711X

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Phosphatase and tensin homolog (PTEN) is a regulator of phosphoinositide 3-kinase signaling and an important tumor suppressor mutated/deleted in human cancers. PTEN deletion in the liver leads to insulin resistance, steatosis, inflammation, and cancer. We recently demonstrated that unsaturated fatty