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MicroRNA as a novel drug target for cancer therapy

✍ Scribed by Liu, Xiaoxia; Liu, Li; Xu, Qian; Wu, Ping; Zuo, Xialin; Ji, Aimin


Book ID
120346031
Publisher
Informa plc
Year
2012
Tongue
English
Weight
216 KB
Volume
12
Category
Article
ISSN
5847-4714

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Growing evidence has demonstrated that clonogenic cancer stem (initiating) cells are responsible for tumor regrowth and disease relapse. Bmi-1 plays a critical role in the self-renewal of adult stem cells. The Bmi-1 protein is elevated in many types of cancers, and experimental reduction of Bmi-1 pr