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microRNA-21-mediated regulation of Sprouty2 protein expression enhances the cytotoxic effect of 5-fluorouracil and metformin in colon cancer cells

✍ Scribed by Tsao, Chao-Jung


Book ID
119991317
Publisher
Spandidos Publications Ltd
Year
2012
Tongue
English
Weight
444 KB
Category
Article
ISSN
1107-3756

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## Abstract Curcumin (diferuloylmethane), which has been shown to inhibit growth of transformed cells, has no discernible toxicity and achieves high levels in colonic mucosa. 5‐fluorouracil (5‐FU) or 5‐FU plus oxaliplatin (FOLFOX) remains the backbone of colorectal cancer chemotherapeutics, but wit