Sorafenib inhibits the shedding of major
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Keisuke Kohga; Tetsuo Takehara; Tomohide Tatsumi; Hisashi Ishida; Takuya Miyagi;
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Article
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2009
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John Wiley and Sons
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English
⚖ 815 KB
The ectodomain of major histocompatibility complex class I-related chain A (MICA) is shed from tumor cells, and may be an important means of evading antitumor immunity. This study investigated the roles of a disintegrin and metalloproteinase 9 (ADAM9) in the shedding of MICA in human hepatocellular