✦ LIBER ✦

Micropatterning of biomedical polymer surfaces by novel UV polymerization techniques

✍ Scribed by Ward, Jennifer H. ;Bashir, Rashid ;Peppas, Nicholas A.

Publisher: John Wiley and Sons
Year: 2001
Tongue: English
Weight: 515 KB
Volume: 56
Category: Article
ISSN: 0021-9304
DOI: 10.1002/1097-4636(20010905)56:3<351::aid-jbm1103>3.0.co;2-a

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✦ Synopsis

The "living" radical polymerization with an iniferter was used to create micropatterned biomedical surfaces. Novel, photosensitive biomedical polymers were created by the incorporation of dithiocarbamate groups from iniferters. A second monomer layer was then irradiated onto the photosensitive polymer substrate created with the iniferter to form a copolymer. Patterns were created on the films by application of modified microfabrication-based photolithographic techniques. The technique was used to create patterns with depths from 5 to 80 m. In addition, various polymers were incorporated, including polyethylene glycol methacrylates, styrene, and methacrylic acid, to synthesize regions with different physico-chemical properties. Applications include novel surfaces for biosensors and biomaterials for the selective adhesion of cells and proteins.

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