Micronucleus formation in peripheral-blood lymphocytes from smokers and the influence of alcohol- and tea-drinking habits
✍ Scribed by Kai-Xian Xue; Su Wang; Guo-Jian Ma; Ping Zhou; Pan-Quan Wu; Rui-Feng Zhang; Zhen Xu; Wen-Sheng Chen; You-Qin Wang
- Book ID
- 102864248
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- French
- Weight
- 587 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
In recent years, studies on the genotoxic effects of smoking and its modifying factors have been widely followed with interest. In this report, frequencies of micronuclei (MNF) in peripheral-blood lymphocytes in 220 healthy smokers have been detected by the micronucleus test by finger-skin puncture, which needs only I to 2 drops of peripheral blood. On the basis of analysis of matched-pair data, the modifying effects of alcohol and tea are discussed. Our results show that (I) smoking significantly increases MNF in lymphocytes as compared with healthy non-smokers (p < 0.01); (2) alcohol significantly increases MNF in smokers (p < 0.01); (3) tea decreases MNF induced by smoking (p C 0.0 I). Therefore, the anti-carcinogenic role of tea merits further study.