✦ LIBER ✦

Micromechanical properties of human trabecular bone: A hierarchical investigation using nanoindentation

✍ Scribed by Jonathan Norman; Joe G. Shapter; Ken Short; Lachlan J. Smith; Nicola L. Fazzalari

Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 235 KB
Volume: 87A
Category: Article
ISSN: 1549-3296
DOI: 10.1002/jbm.a.31766

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The ability to assess the risk of fracture, evaluate new therapies, predict implant success and assess the influence of bone remodeling disorders requires specific measurement of local bone micromechanical properties. Nanoindentation is an established tool for assessing the micromechanical properties of hard biological tissues. In this study, elastic modulus and hardness were quantified using nanoindentation for human trabecular bone from the intertrochanteric region of the proximal femur. These properties were demonstrated to be heterogeneous and highly correlated at the intraspicule, interspicule, and interspecimen levels. The results of this study have important implications for current understanding of structure–function relationships throughout the trabecular bone structural hierarchy. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2008

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