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Microglia progenitor cells: A subpopulation in cultures of mouse neopallial astroglia

โœ Scribed by A. Richardson; C. Hao; S. Fedoroff

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
877 KB
Volume
7
Category
Article
ISSN
0894-1491

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โœฆ Synopsis

We have shown that astroglia cultures initiated from newborn mouse neopallium contain microglia progenitor cells. Astroglia secrete growth factor( s) that transform the progenitor cells into microglia. One of the trophic factors is bone marrow macrophage growth factor CSF-1. Mouse embryonic fibroblast cells STO also secrete trophic factor(s) that acts synergistically o r additively with CSF-I on microglia progenitor cells. Using limiting dilution analysis we estimated that in the presence of CSF-1 and STO cells, 1 in every 8 cells in astroglia cultures is a potential microglia progenitor cell. t \ 1993 Wiley-Llss, Inc ( a ) were grown in regular medium with the STO feeder layer or 1 . 1

were grown with the STO feeder layer in regular niedium to which 20% LM cell conditioned medium containing CSF-1 was added. In all cultures the total number of cells was the same? but the ratio between astroglia and irradiated STO cells varied (see text).

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