Microglia dynamics and function in the CNS
โ Scribed by Christopher N Parkhurst; Wen-Biao Gan
- Book ID
- 113553041
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 260 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0959-4388
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Microglia are immunocompetent cells of the brain that continuously survey their environment with highly motile extensions. Although first described almost a century ago, the developmental origin of microglia is still debated. Besides early myeolomonocytic cell populations that colonize the developin
Microglia demonstrate many characteristics similar to those seen in rnonocytes and tissue-specific rnacrophages, including phagocytosis, production of oxygen radicals, and growth factors and expression of MHC antigens. We have examined the ability of microglia, cultured from the cerebral cortices of