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Microfluidic devices for the analysis of apoptosis

✍ Scribed by Jianhua Qin; Nannan Ye; Xin Liu; Bingcheng Lin

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
581 KB
Volume
26
Category
Article
ISSN
0173-0835

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✦ Synopsis

Apoptosis is the outcome of a metabolic cascade that results in cell death in a controlled manner. Due to its important role in maintaining balance in organisms, in mechanisms of diseases, and tissue homeostasis, apoptosis is of great interest in the emerging fields of systems biology. Research into cell death regulation and efforts to model apoptosis processes have become powerful drivers for new technologies to acquire ever more comprehensive information from cells and cell populations. The microfluidic technology promises to integrate and miniaturize many bioanalytical processes, which offers an alternative platform for the analysis of apoptosis. This review aims to highlight the recent developments of microfluidic devices in measuring the hallmarks as well as the dynamic process of cellular apoptosis. The potential capability and an outlook of microfluidic devices for the study of apoptosis are addressed.

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