Microfluidic Cell Culture Systems

• Publisher: William Andrew
• Year: 2011
• Tongue: English
• Leaves: 429
• Edition: 1
• Category: Library

✦ Synopsis

The fields of microfluidics and BioMEMS are significantly impacting cell biology research and applications through the application of engineering solutions to human disease and health problems. The dimensions of microfluidic channels are well suited to the physical scale of biological cells, and the many advantages of microfluidics make it an attractive platform for new techniques in biology.

This new professional reference applies the techniques of microsystems to cell culture applications. The authors provide a thoroughly practical guide to the principles of microfluidic device design and operation and their application to cell culture techniques. The resulting book is crammed with strategies and techniques that can be immediately deployed in the lab. Equally, the insights into cell culture applications will provide those involved in traditional microfluidics and BioMEMS with an understanding of the specific demands and opportunities presented by biological applications.

The goal is to guide new and interested researchers and technology developers to the important areas and state-of-the-practice strategies that will enhance the efficiency and value of their technologies, devices and biomedical products.

• Provides insights into the design and development of microfluidic systems with a specific focus on cell culture applications
• Focuses on strategies and techniques for the design and fabrication of microfluidic systems and devices for cell culture
• Provides balanced coverage of microsystems engineering and bioengineering

✦ Table of Contents

Content:
Front-matter, Pages i,iii
Copyright, Page iv
Preface, Pages xiii-xvi, Jeffrey T. Borenstein
List of Contributors, Pages xvii-xx, Molly Allen, Hojae Bae, Leon M. Bellan, Jeffrey T. Borenstein, Holly Chamberlain, Joseph L. Charest, Seok Chung, Carolyn G. Conant, Nicholas J. Douville, Else M. Frohlich, Brian M. Gillette, Stefan Giselbrecht, Eric Gottwald, Linda G. Griffith, James B. Grotberg, Jen-Huang Huang, Paul Hung, Anne Hsieh, Niraj K. Inamdar, Cristian Ionescu-Zanetti, et al.
Chapter 1 - Microfluidic Cell Culture Platforms with Embedded Nanoscale Features, Pages 3-26, Yong Yang, Kam W. Leong
Chapter 2 - Microvascular Networks for Tissue Engineering, Pages 27-52, Jen-Huang Huang, Arul Jayaraman, Victor M. Ugaz
Chapter 3 - Microfluidics for Engineering 3D Tissues and Cellular Microenvironments, Pages 53-79, Brian M. Gillette, Hesam Parsa, Samuel K. Sia
Chapter 4 - Fabrication of Advanced Microcontainer Arrays for Perfused 3D Cell Culture in Microfluidic Bioreactors, Pages 81-104, Roman Truckenmüller, Stefan Giselbrecht, Eric Gottwald, Arne Schleunitz
Chapter 5 - Mechanobiological Approaches for the Control of Cell Motility, Pages 105-136, Sang-Hee Yoon, Young Kyun Kim, Mohammad R.K. Mofrad
Chapter 6 - Transport Models for Three-Dimensional Cell Culture Systems, Pages 137-172, Niraj K. Inamdar, Linda G. Griffith, Jeffrey T. Borenstein
Chapter 7 - Microfluidic Systems for Controlling Stem Cells Microenvironments, Pages 175-203, Šeila Selimović, Hirokazu Kaji, Hojae Bae, Ali Khademhosseini
Chapter 8 - Vascularization of Microfluidic Hydrogels, Pages 205-221, Joe Tien, Keith H.K. Wong, James G. Truslow
Chapter 9 - Microfluidic Vascular Networks for Engineered Tissues, Pages 223-245, Leon M. Bellan, Holly Chamberlain, Diana Wu, Robert Langer
Chapter 10 - Microfluidic Approaches Toward Pulmonary Tissue Constructs, Pages 247-278, Joshua B. White, Nicholas J. Douville, Christopher Moraes, James B. Grotberg, Shuichi Takayama
Chapter 11 - Microfabricated Kidney Tissue Models, Pages 279-302, Else M. Frohlich, Joseph L. Charest
Chapter 12 - Microfluidic Cell Culture Techniques, Pages 303-321, Yun Xiao, Boyang Zhang, Anne Hsieh, Nimalan Thavandiran, Cristina Martin, Milica Radisic
Chapter 13 - Functionalized Microfluidic Devices for Separation of Cell Phenotypes, Pages 325-340, Beili Zhu, Brian D. Plouffe, Shashi K. Murthy
Chapter 14 - Microfluidic Hepatotoxicity Platform, Pages 341-355, Philip Lee, Molly Allen, Paul Hung
Chapter 15 - Live Cell Analysis Under Shear Flow, Pages 357-383, Carolyn G. Conant, J. Tanner Nevill, Cristian Ionescu-Zanetti
Chapter 16 - Microfluidic Platforms for Evaluating Angiogenesis and Vasculogenesis, Pages 385-403, Jessie S. Jeon, Seok Chung, Roger D. Kamm
Chapter 17 - Cardiovascular Disease/Discovery Models, Pages 405-421, Vivienne Williams, Dmitry Kashanin, Toby Paul, Sara Pizzato
Index, Pages 423-433