Microfabrication of Stimuli-Responsive Polymers

✍ Scribed by Chuanliang Feng, Xiaoqiu Dou, Yibin Xu

• Publisher: Springer
• Year: 2021
• Tongue: English
• Leaves: 194
• Category: Library

✦ Synopsis

This book introduces readers to interfacial reactions in confinement on stimuli-responsive homopolymer and diblock copolymer films. It also includes investigations concerning the immobilization of (bio)molecules and the fabrication of biomolecular patterns by reactive microcontact printing on these reactive polymer films. In turn, the book takes advantage of the microphase separation of diblock copolymer films to study the fabrication of nanopatterns, which could contribute to the future development of a model system that allows us to area-selectively deposit and address (bio)molecules. Given its scope, the book broadens readers’ perspective on the microfabrication of stimuli-responsive polymers.

✦ Table of Contents

Preface
Contents
Abbreviations
1 Reactive Platforms for Controllable Fabrication of Functional (Bio)Interfaces
1.1 Scope of Surface Modification for (Bio)Reactive Platforms and Functional (Bio)Interfaces
1.2 Chemical and Topographical Pattern Fabrication from Micrometer to Nanometer Length Scales
References
2 Surface Reactions and Fabrication of Bioreactive Platforms Based on Organic and Polymeric Films: From Micrometer to Nanometer Length Scale
2.1 Introduction: Bioreactive Platforms and Biointerfaces via Organic and Polymeric Films
2.1.1 Organic and Polymeric Films
2.1.2 Pattern Fabrication on Organic and Polymeric Films
2.2 Surface Reactions of Organic and Polymeric Films
2.2.1 Self-assembled Monolayers
2.2.2 Surface Modification with Polymers
2.3 Patterned Organic and Polymeric Films for Tailored (Bio)Interfaces
2.3.1 Microcontact Printing
2.3.2 Selective Molecular Assembly Patterning (SMAP)
2.3.3 Embossing and Nano-Imprinting
2.3.4 Self-assembled Block Copolymer Patterns
References
3 Confinement Effects on the Reactivity in Ultrathin Polymer Films: Kinetics and Temperature Dependence of the Hydrolysis of NHS and TBA Esters
3.1 Introduction
3.2 Ultrathin PNHSMA Polymer Films
3.2.1 Characterization of the Hydrolysis of PNHSMA Films
3.2.2 Temperature Dependence of Reaction Kinetics
3.2.3 Comparison of Surface Reactions in SAMs and Ultrathin Polymer Films
3.3 Ultrathin PSn-b-PtBAm Polymer Films
3.3.1 Characterization of Polymer Thin Film Surface Composition
3.3.2 Characterization and Kinetics of the Hydrolysis of PSm-b-PtBAn Films
3.3.3 Investigation of the Temperature Dependence of Reaction Kinetics
3.3.4 Effects of Film Thickness and Thermal Pretreatment on Reaction Rates
3.3.5 Dependence of Hydrolysis Kinetics on Surface Composition
3.3.6 Comparison of Reactivity of T-Butyl Esters in PSn-b-PtBAm Thin Films and in Solution
3.4 Experimental Section
References
4 Reactive Thin Polymer Films as Platforms for the Immobilization of Biomolecules
4.1 Introduction
4.2 Investigation of the Reactivity of PNHSMA
4.2.1 Coupling of PEG500-NH2
4.2.2 Coupling of Fluoresceinamine and BSA to PNHSMA Films
4.2.3 Comparison of Surface Reactions on PNHSMA Films and NHS-C10 Monolayers
4.3 Swelling Behavior and Stability of PNHSMA Films
4.4 Immobilization of DNA and Surface-Based Hybridization
4.4.1 DNA Immobilization Studied by SPR
4.4.2 Investigation of DNA Hybridization by SPFS and Fluorescence Microscopy
4.5 Toward the Detection of Pathogenic Bacteria on PNHSMA Films
4.6 Experimental Section
References
5 Tailored Biointerfaces via Derivatization of Polystyrene-b-Poly(Tert-Butyl Acrylate) Thin Films
5.1 Introduction
5.2 Investigation of the Surface Chemistry of PS690-b-PtBA1210 Films
5.2.1 Surface Hydrolysis of PS690-b-PtBA1210 Films
5.2.2 Covalent Coupling of PEG to Activated PS690-b-PtBA1210 Films
5.3 Covalent Coupling of Biomolecules to Activated PS690-b-PtBA1210 Films
5.4 Cell Adhesion Studies on PS690-b-PtBA1210 Films
5.5 Experimental Section
References
6 Fabrication of Robust Biomolecular Patterns by Reactive Microcontact Printing on NHS Ester Containing Polymer Films
6.1 Introduction
6.2 Approaches for Micropatterning of PNHSMA Films
6.3 Functionalization of PNHSMA Films by Reactive μCP
6.4 Non-specific Adsorption (NSA)
6.5 Patterning of PNHSMA and Coupling of (Bio)Molecules to Patterned Films
6.6 DNA Hybridization
6.7 Experimental Section
References
7 Reactive μCP on Ultrathin Block Copolymer Films: Investigation of the μCP Mechanism and Applications to Sub-μm (Bio)Molecular Patterning
7.1 Introduction
7.2 Strategy A: Fabrication of Multimolecular Arrays by Direct Molecular Transfer
7.3 Strategy B: Local Passivation of PS690-b-PtBA1210 Films
7.4 Strategy C: Local Deprotection of PS690-b-PtBA1210 Films
7.4.1 Analysis by Fluorescence Microscopy
7.4.2 Analysis by AFM
7.4.3 Mechanism of Local Hydrolysis
7.4.4 Local Deprotection on the Sub-μm Scale
7.5 Experimental Section
References
8 Nanofabrication on Reactive Block Copolymer Film Platforms: Toward Microdomain-Selective Chemical Functionalization
8.1 Introduction
8.2 Solvent-Induced Surface Reorientation of PS-b-PtBA Films
8.3 Domain-Selective Coupling on Solvent-Treated Polymer Films
8.3.1 Global Characterization of Domain-Selective Coupling
8.3.2 Characterization of Domain-Selective Coupling at the Nanometer Level
8.4 Area-Selective Functionalization of Block Copolymer-Based Nanopatterned Platforms
8.5 Outlook
8.6 Experimental Section
References
9 Bioinspired Hierarchically Structured Polymer Interfaces for Promising Biomedical Applications
9.1 Introduction
9.2 Preparation of Rose Petal-Derived PDMS Surface Functionalized with Anti-EpCAM
9.2.1 Fabrication of Hierarchically Structured PDMS
9.2.2 Chemical Modification of Anti-EpCAM on Hierarchically Structured PDMS Surface
9.3 Cell-Capture on Functionalized Hierarchical PDMS
9.3.1 Cell-Capture
9.3.2 Cell Release
9.4 Conclusion and Outlook
9.5 Experimental Section
References