Microenvironment revisited: Time for reappraisal of some prevailing concepts of cancer metastasis
✍ Scribed by Øystein Fodstad; Inge Kjønniksen
- Book ID
- 102877705
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 646 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0730-2312
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
The development and biological characteristics of tumor metastasis are influenced by multiple cell and host‐associated factors. To study these factors experimentally, the necessity of choosing adequate in vivo model systems for human tu mor metastasisis emphasized. Recent research has provided results that highlight the role of the microenvironment in determining important characteristics of the metastatic cells, including their degree of differentitation and sensitivity to drugs. Furthermore, evidence is presented as background for discussing the general validity of the notion of clonal selection of metastatic, and whether the metastatic phenotype is acquired through the last of a series of mutational events occurring during tumor progression.