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Microencapsulation of mitomycin C for controlled delivery and targeting

✍ Scribed by TL Whateley; JG Eley; I Crossan; PB Deasy


Book ID
113275832
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
141 KB
Volume
28
Category
Article
ISSN
0168-3659

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In 10 human cancer cell lines, the activity of mitomycin C (MMC) was found to be determined by an interplay between activation by DT-diaphorase (DTD) and inactivation by glutathione S-transferase (GST). NADPH/cytochrome P-450 reductase was not responsible for MMC activation and expression of MDR1 (M