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Microelectronic DNA Assay for the Detection of BRCA1 Gene Mutations

โœ Scribed by Hua Chen; Jie Han; Jun Li; Meyya Meyyappan

Book ID
111574642
Publisher
Springer
Year
2004
Tongue
English
Weight
164 KB
Volume
6
Category
Article
ISSN
1387-2176

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## Abstract In most families with multiple cases of breast and ovarian cancer, the cancer appears to be associated with germline alterations in __BRCA1__ or __BRCA2__. However, somatic mutations in __BRCA1__ and __BRCA2__ in sporadic breast and ovarian tumors are rare, even though loss of heterozyg