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Microdissecting the Genetic Events in Nephrogenic Rests and Wilms' Tumor Development

โœ Scribed by Adrian K. Charles; Keith W. Brown; P. Jeremy Berry


Book ID
117022819
Publisher
American Society for Investigative Pathology
Year
1998
Tongue
English
Weight
844 KB
Volume
153
Category
Article
ISSN
0002-9440

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Nephrogenic rests and the pathogenesis o
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Nephrogenic rests (NR) are abnormally persistent clusters of embryonal cells, representing microscopic malformations (dysplasias) of the developing kidney. Though NR are best known as precursors of Wilms tumor (WT), many alternative fates are observed, and most rests are destined for eventual atresi

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Our objechves include: i) determirung correlations between Wilms' tumor-specific molecular genehc events and clinicopathologc features; (ii) identifyrig hrther DNA/chromosomal aberrations; and (iii) establishing a Wilms' tumor tissue bank. To this end, a Witms' tumor biology protocol has been develo