Microdialysis Sampling Method for Evaluation of Binding Kinetics of Small Molecules to Macromolecules
β Scribed by Wang, Hailin; Wang, Zhixin; Lu, Meiling; Zou, Hanfa
- Book ID
- 121490843
- Publisher
- American Chemical Society
- Year
- 2008
- Tongue
- English
- Weight
- 124 KB
- Volume
- 80
- Category
- Article
- ISSN
- 0003-2700
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π SIMILAR VOLUMES
A mathematical analysis of the dynamic dialysis process is presented, demonstrating how the process can be applied generally to study competitive and noncompetitive binding between small molecules and macromolecules. A law of mass action model for competitive binding with independent sites and class
The conformational entropy is the largest unfavorable effect that must be overcome during protein folding and binding. Accurate predictions of protein stability and binding affinity require a precise way of evaluating conformational entropy changes. Previously we implemented a computational approach