Microdensitometry of T2-weighted magnetic resonance (MR) images from patients with advanced neoplasias in a phase I clinical trial of an infrared pulsed laser device (IPLD)
✍ Scribed by Luis A. Santana-Blank; Heberto Reyes; Elizabeth Rodríguez-Santana; Karin E. Santana-Rodríguez
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 175 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0196-8092
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✦ Synopsis
Abstract
Background and Objective
The aim of this study was to determine whether an infrared pulsed laser device (IPLD)‐induced pathophysiologic changes could be identified before measurable modifications in tumor volume.
Study Design/Patients and Methods
Pre‐and post‐IPLD treatment magnetic resonance (MR) images of tumor heterogeneities and peritumoral tissues were digitized and a linear transformation was performed to convert images to 256 intensity levels. Data were analyzed by using the Student's t‐test and the Kolmogorov–Sminov test (α = 0.05).
Results
The post‐treatment mean intensity values of tumor heterogeneities increased significantly (P<0.001) for all of the seven patients (n = 7) evaluated. For peritumoral tissues, a significant increase (P<0.001) was measured in four patients (n = 4). The Kolmogorov–Sminov test showed significant values for the tumor tissue of six (n = 6) patients.
Conclusion
This is the first study of early evidence of anti‐cancer activity of a novel IPLD showing a significant increase in the water content of tumor heterogeneities before measurable changes in tumor volume. Lasers Surg. Med. 34:398–406, 2004. © 2004 Wiley‐Liss, Inc.