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Microcirculatory responses to vascular washout following ischemia

✍ Scribed by Scott T. Howell; Anthony V. Seaber; James R. Urbaniak

Publisher: John Wiley and Sons
Year: 1989
Tongue: English
Weight: 398 KB
Volume: 10
Category: Article
ISSN: 0738-1085
DOI: 10.1002/micr.1920100403

No coin nor oath required. For personal study only.

✦ Synopsis

This study examined the microcirculatory alterations in the hindlimb of the rat caused by ischemia and vascular washout with lactated Ringer's solution. Experimental groups consisted of innervated and denervated animals, each subjected to 2 hours of hindlimb ischemia. The ischemic period was then followed by either vascular washout or no washout prior to reperfusion. The cutaneous capillary blood flow was measured using laser Doppler velocimetry. The results demonstrated a substantial increase in early reperfusion flow above baseline in the innervated groups, more apparent in the group subjected to vascular washout. In all cases where there was elevated early flow, later flow levels were decreased. The results and proposed mechanisms of the response are discussed.

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