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Microcephaly-lymphedema-chorioretinal dysplasia: A unique genetic syndrome with variable expression and possible characteristic facial appearance

✍ Scribed by Limwongse, Chanin; Wyszynski, Richard E.; Dickerman, Lois H.; Robin, Nathaniel H.

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 36 KB
Volume: 86
Category: Article
ISSN: 0148-7299
DOI: 10.1002/(sici)1096-8628(19990917)86:3<215::aid-ajmg4>3.0.co;2-e

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✦ Synopsis

We report on a follow-up examination of a family with microcephaly and lymphedema. The finding of chorioretinal dysplasia with variable visual deficit in multiple relatives, which was not previously discovered, supports the concept of microcephaly, lymphedema, and chorioretinopathy as being a single autosomal dominant genetic entity with variable expression. We recommend that fundoscopic examination be performed in all patients with microcephaly with or without lymphedema.

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