Chinese hamster ovary cell production of recombinant tissue-type plasminogen activator (t-PA) was increased by amplification of cotransfected dihydrofolate reductase cDNA using stepwise adaptation to increasing methotrexate (MTX) concentrations. The highest producing clones were isolated at 5 ยตM MTX
Microcarrier culture of recombinant Chinese hamster ovary cells for production of human immune interferon and human tissue-type plasminogen activator
โ Scribed by Kjell Nilsson; Staffan Birnbaum; Klaus Mosbach
- Publisher
- Springer
- Year
- 1988
- Tongue
- English
- Weight
- 514 KB
- Volume
- 27
- Category
- Article
- ISSN
- 1432-0614
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