Microbial Transformation of Nandrolone Decanoate by Acremonium Strictum
✍ Scribed by Mojtaba Tabatabaei Yazdi; Seyedeh Maryam Zanjanian; Mohammad Ali Faramarzi; Mohsen Amini; Amir Amani; Khosrou Abdi
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 642 KB
- Volume
- 339
- Category
- Article
- ISSN
- 0365-6233
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✦ Synopsis
Abstract
Estr‐4‐en‐3,17‐dione II, 17β‐hydroxyestr‐4‐en‐3‐one III, 15α‐hydroxyestr‐4‐en‐3,17‐dione IV, and 15α,17β‐dihydroxyestr‐4‐en‐3‐one V were produced by microbial transformation of nandrolone decanoate I in the culture of Acremonium strictum PTCC 5282. Bioconversion characteristics observed were ester hydrolysis, oxidation, and hydroxylation. Each microbial product was purified chromatographically and characterized on the basis of spectral data obtained from ^1^H‐NMR, ^13^C‐NMR, FT‐IR, MS, and physical constants such as melting point and optical rotation.
📜 SIMILAR VOLUMES
Biotransformation of furfural by Succhuromyces cerevisiae 354 was performed in a sugar cane molasses medium containing salts. The furfural added was rapidly reduced to furfuryl alcohol until a final addition of 3%, without inhibition in the ceIls growth. An efficient conversion o f 96% was obtained