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Microbial transformation of cannabinoids. Part 3: Major metabolites of (3R, 4R)-Δ1-tetrahydrocannabinol

✍ Scribed by Michael Binder; Astrid Popp

Publisher
John Wiley and Sons
Year
1980
Tongue
German
Weight
249 KB
Volume
63
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

The metabolic transformations of the psychotropic cannabinoid (3__R__, 4__R__)‐Δ^1^‐tetrahydrocannabinol (5) (=Δ^1^‐THC) by cultures of Fusarium Nivale, Gibberella fujikuroi (both Ascomycetes) and Thamnidium elegans (Phycomycetes) were investigated. A number of metaboilites, 1–4 and 6–9 were isolated from the incubations, partly purified and their structures elucidated by combined gas chromatography/mass spectrometry. Four of these metabolites, 1″‐hydroxy‐Δ^1^‐THC (4) 2″‐hydroxy‐β^1^‐THC (1) 6Δ‐hydroxy‐ζ^1^‐THC (8) and 2″,6Δ‐dihydroxy‐Δ^1^‐THC (9) so far have not been reported as microbial transformation products of 5.

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