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Microbial Structures in a Patient With Sporadic Non-A, Non-B Fulminant Hepatitis Treated by Liver Transplantation

✍ Scribed by Elizabeth A. Fagan; David S. Ellis; Bernard Portmann; George M. Tovey; Roger Williams; Professor Arie J. Zuckerman

Publisher: John Wiley and Sons
Year: 1987
Tongue: English
Weight: 658 KB
Volume: 22
Category: Article
ISSN: 0146-6615
DOI: 10.1002/jmv.1890220211

No coin nor oath required. For personal study only.

✦ Synopsis

Double-shelled virus-like particles (60 nm) and long cytoplasmic tubular structures were found in the cytoplasm of hepatocytes from areas of collapsed and regenerating areas of hepatectomised liver in a 13-year-old boy who received a liver graft for fulminant hepatitis attributed to sporadic non-A, non-B hepatitis. The patient died on the ninth postoperative day from acute graft failure. Although virus-like particles were not found, instead, gram-negative rods were identified in the necrotic graft and the most likely cause of death was a gram-negative septicaemia with a Shwartzman-like reaction localized to the liver.

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