Microbial dehalogenation

✍ Scribed by Dick B Janssen; Jantien E Oppentocht; Gerrit J Poelarends

• Book ID: 104361566
• Publisher: Elsevier Science
• Year: 2001
• Tongue: English
• Weight: 61 KB
• Volume: 12
• Category: Article
• ISSN: 0958-1669
• DOI: 10.1016/s0958-1669(00)00208-1

✦ Synopsis

Novel dehalogenases have been identified recently in various bacteria that utilise halogenated substrates. X-ray studies and sequence analysis have revealed insight into the molecular mechanisms of hydrolytic dehalogenases. Furthermore, genetic and biochemical studies have indicated that reductive dehalogenases are extra-cytoplasmic corrinoid-containing iron-sulphur proteins. Sequence analysis and mutagenesis studies indicate that several dehalogenases are homologous to enzymes that carry out transformations on non-halogenated substrates.