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Microbial Asymmetric Catalysis—Enantioselective Reduction of Ketones [New Synthetic Methods (45)]

✍ Scribed by Prof. Charles J. Sih; Ching-Shih Chen

Book ID
102725612
Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
847 KB
Volume
23
Category
Article
ISSN
0044-8249

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Reduction of Carbonyl Compounds with Chi
Reduction of Carbonyl Compounds with Chiral Oxazaborolidine Catalysts: A New Paradigm for Enantioselective Catalysis and a Powerful New Synthetic Method
✍ Elias J. Corey; Christopher J. Helal 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 527 KB

High enantioselectivity can be achieved when chiral oxazaborolidines are used as catalysts in the reduction of ketones by borane. In the transition state on the way to the complex chiral compounds, the two reactants are activated and held in close proximity by the catalyst, as shown below.